Published January 3, 2013
| Version v1
Journal article
Long-range macromolecule interaction and "speed reading" long nucleotide sequences in DNA
- 1. Moscow Lomonosov State University, Skobeltsyn Institute of Nuclear Physics, 1(2), Leninskie Gory, GSP-1, Moscow 119991 (Russian Federation)
- 2. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova Str., 32, GSP-1, Moscow 119991 (Russian Federation)
- 3. Moscow Institute of Physics and Technology, Institutskii per., 9, Dolgoprudny, Moscow Region 141700 (Russian Federation)
Description
Methods based on the phenomenon of the specific long-range interaction between long macromolecules proposed for "speed reading" nucleotide sequences in single DNA molecules. One way is to measure the electric field potential along the preliminary stretched double DNA strand. Another way of information "reading" is to measure deformation of strand elements caused by an electric field that is generated by the "straightening" electrode due to an alternating voltage applied to it. On the base of the obtained information the sequence of nucleotides in the strand could be determined in principle.
Availability note (English)
Available from http://dx.doi.org/10.1016/j.physleta.2012.11.029Additional details
Identifiers
- DOI
- 10.1016/j.physleta.2012.11.029;
- PII
- S0375-9601(12)01184-X;
Publishing Information
- Journal Title
- Physics Letters. A
- Journal Volume
- 377
- Journal Issue
- 3-4
- Journal Page Range
- p. 323-328
- ISSN
- 0375-9601
- CODEN
- PYLAAG
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 45113639
- Subject category
- S71: CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS;
- Descriptors DEI
- ATOMIC FORCE MICROSCOPY; DEFORMATION; DNA; ELECTRIC FIELDS; ELECTRIC POTENTIAL; INFORMATION; INTERACTION RANGE; INTERACTIONS; MOLECULES; NUCLEOTIDES; READOUT SYSTEMS; SUBSTRATES
- Descriptors DEC
- DISTANCE; MICROSCOPY; NUCLEIC ACIDS; ORGANIC COMPOUNDS
Optional Information
- Copyright
- Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.