Published January 3, 2013 | Version v1
Journal article

Long-range macromolecule interaction and "speed reading" long nucleotide sequences in DNA

  • 1. Moscow Lomonosov State University, Skobeltsyn Institute of Nuclear Physics, 1(2), Leninskie Gory, GSP-1, Moscow 119991 (Russian Federation)
  • 2. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova Str., 32, GSP-1, Moscow 119991 (Russian Federation)
  • 3. Moscow Institute of Physics and Technology, Institutskii per., 9, Dolgoprudny, Moscow Region 141700 (Russian Federation)

Description

Methods based on the phenomenon of the specific long-range interaction between long macromolecules proposed for "speed reading" nucleotide sequences in single DNA molecules. One way is to measure the electric field potential along the preliminary stretched double DNA strand. Another way of information "reading" is to measure deformation of strand elements caused by an electric field that is generated by the "straightening" electrode due to an alternating voltage applied to it. On the base of the obtained information the sequence of nucleotides in the strand could be determined in principle.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.physleta.2012.11.029

Additional details

Identifiers

DOI
10.1016/j.physleta.2012.11.029;
PII
S0375-9601(12)01184-X;

Publishing Information

Journal Title
Physics Letters. A
Journal Volume
377
Journal Issue
3-4
Journal Page Range
p. 323-328
ISSN
0375-9601
CODEN
PYLAAG

INIS

Country of Publication
Netherlands
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
45113639
Subject category
S71: CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS;
Descriptors DEI
ATOMIC FORCE MICROSCOPY; DEFORMATION; DNA; ELECTRIC FIELDS; ELECTRIC POTENTIAL; INFORMATION; INTERACTION RANGE; INTERACTIONS; MOLECULES; NUCLEOTIDES; READOUT SYSTEMS; SUBSTRATES
Descriptors DEC
DISTANCE; MICROSCOPY; NUCLEIC ACIDS; ORGANIC COMPOUNDS

Optional Information

Copyright
Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.