Utilization of time-dose-fractionated models in planning of radiotherapy of malignant tumors

New methods of the fractionation of preoperative #betta#-beam therapy for breast carcinoma and intracavitary irradiation of cervical cancer patients with 252Cf fast neutron sources have been devised and tested on the basis of the concept of a cumulative radiation effect (CRE) and the system of TDF factors. In the selection of regimens of the fractionation of intracavitary irradiation of cervical cancer with 252Cf fast neutrons using the system of TDF factors one should take into account the RBE of the type of radiation that would be equal to 5 by the criterion of a direct response of a tumor within the range of dose rates between 20-30 s Gy/hr. Taking account of a short period of half-life of 252Cf sources fractionation schemes should be corrected from the view-point of the system of TDF factors not less than once ine 2-3 months