Published August 2006
| Version v1
Journal article
Automated synthesis of 3'-Deoxy-3'-Fluorothymidine as metabolize imaging agent
- 1. Shandong Tumor Hospital, Jinan (China). PET-CT Center
Description
3'-Deoxy-3'-Fluorothymidine (18F-FLT) is synthesized by 'BAThy' method at Tracerlab FXf-N system. By using 5'-O-benzoyl-2,3-anhydro-thymidine (BAThy) as the precursor, 18F-FLT is obtained by two step reactions, including the nucleophilic fluoration and hydrolysis. The synthesis can be completed about 50 min. The radiochemical yield and radiochemical purity are about 10% and 95%, respectively. The procedure is guide simple and automated synthesis. (authors)
Additional details
Publishing Information
- Journal Title
- Journal of Nuclear and Radiochemistry
- Journal Volume
- 28
- Journal Issue
- 3
- Journal Page Range
- p. 174-177
- ISSN
- 0253-9950
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 38098434
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- AUTOMATION; FLUORINATION; FLUORINE 18; HYDROLYSIS; IMAGES; IMPURITIES; METABOLISM; ORGANIC FLUORINE COMPOUNDS; PRECURSOR; RADIOPHARMACEUTICALS; SYNTHESIS; THYMIDINE; YIELDS
- Descriptors DEC
- AZINES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CHEMICAL REACTIONS; DECOMPOSITION; DRUGS; FLUORINE ISOTOPES; HALOGENATION; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; LYSIS; MATERIALS; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; NUCLEOSIDES; NUCLEOTIDES; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIOACTIVE MATERIALS; RADIOISOTOPES; RIBOSIDES; SOLVOLYSIS
Optional Information
- Notes
- 2 figs., 5 refs.