Published August 2002
| Version v1
Journal article
Synthesis of N-succinimidyl-4-18F(fluoromethyl) benzoate
- 1. Chinese Academy of Sciences, Shanghai (China). Shanghai Inst. of Nuclear Research
Description
N-succinimidyl-4-18F-(fluoromethyl) benzoate (18F-SFMB) of labelling proteins has been synthesized. Laborious and time-consuming HPLC is substituted by simple Sep-pak silica during the process of isolation. Many factors affecting the radiochemical synthesis of 18F-SFMB including reaction solvents, temperature, the mole ratio of K/222 to K2CO3 and reaction time are studied. The better labelling conditions are as follows: dry acetonitrile as solvent, the mole ratio of K/222 to K2CO3 is 1:1, reaction time is 5 min at 80 degree C. The radiochemical yield is about 57% (EOS) which is about 3 times higher than the published data. IgG is indirectly labelled by 18F-SFMB and the labelled yield are about 88% at room temperature
Additional details
Publishing Information
- Journal Title
- Journal of Nuclear and Radiochemistry
- Journal Volume
- 24
- Journal Issue
- 3
- Journal Page Range
- p. 157-160
- ISSN
- 0253-9950
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 34076407
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- BENZOIC ACID; CHEMICAL PREPARATION; CHEMICAL REACTION YIELD; ESTERS; FLUORINE 18; IMIDES; IMMUNOGLOBULINS; LABELLING
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; FLUORINE ISOTOPES; GLOBULINS; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MONOCARBOXYLIC ACIDS; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PROTEINS; RADIOISOTOPES; SYNTHESIS; YIELDS