Published May 2019
| Version v1
Journal article
Unique mechanistic insights into the beneficial effects of angiotensin-(1-7) on the prevention of cardiac fibrosis: A metabolomic analysis of primary cardiac fibroblasts
Creators
- 1. Department of Cardiology, the 2nd Affiliated Hospital of Chongqing Medical University (China)
- 2. Departments of Biomedical Engineering and Pediatrics, Emory University, Atlanta, GA 30322 (United States)
- 3. Mass Spectrometry Centre, China-Canada-New Zealand Joint Laboratory of Maternal and Foetal Medicine, Chongqing Medical University (China)
- 4. Liggins Institute, University of Auckland (New Zealand)
- 5. Department of Obstetrics and Gynecology, the 1st Affiliated Hospital of Chongqing Medical University (China)
Description
Cell metabolic pathways are highly conserved among species and change rapidly in response to drug stimulation. Therefore, we explore the effects of angiotensin-(1-7) in a primary cell model of cardiac fibrosis established in angiotensin II-stimulated cardiac fibroblasts via metabolomics analysis and further clarify the potential protective mechanism of angiotensin-(1-7).
Additional details
Identifiers
- DOI
- 10.1016/j.yexcr.2019.03.006;
- PII
- S0014482719300941;
Publishing Information
- Journal Title
- Experimental Cell Research
- Journal Volume
- 378
- Journal Issue
- 2
- Journal Page Range
- p. 158-170
- ISSN
- 0014-4827
- CODEN
- ECREAL
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 55044468
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- ANGIOTENSIN; BIOLOGICAL PATHWAYS; CELL CULTURES; FIBROBLASTS; FIBROSIS; STIMULATION
- Descriptors DEC
- ANIMAL CELLS; CARDIOVASCULAR AGENTS; CONNECTIVE TISSUE CELLS; DRUGS; GLOBULINS; ORGANIC COMPOUNDS; PATHOLOGICAL CHANGES; PROTEINS; SOMATIC CELLS; VASOCONSTRICTORS
Optional Information
- Copyright
- Copyright (c) 2019 Published by Elsevier Inc.