Published May 1983
| Version v1
Journal article
Increase of DNA radiosensitivity under the effect of reducible nitroimidazoles and nitrofurans
Description
It was shown that active radiosensitizers, nitroimidazole and nitrofuran, reduced chemically and enzymatically under anaerobic conditions in the presence of DNA, cause singlestrand breaks in the latter. When this modified DNA is exposed to ionizing radiation the yield of single-strand breaks increases as compared to control (unmodified) DNA
Additional details
Additional titles
- Original title (Russian)
- Увеличение радиочувствительности DNK под действием восстанавливающихся производных нитроимидазола и нитрофурана
Publishing Information
- Journal Title
- Radiobiologiya
- Journal Volume
- 23
- Journal Issue
- 3
- Series
- Radiobiologiya.
- Journal Page Range
- 291-295
- ISSN
- 0033-8192
INIS
- Country of Publication
- Russian Federation
- Country of Input or Organization
- USSR
- INIS RN
- 15013264
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL REPAIR; CATALYSIS; DNA; DOSE-RESPONSE RELATIONSHIPS; ELECTROPHORESIS; LIVER; METABOLISM; OXIDASES; RADIOSENSITIVITY; RADIOSENSITIZERS; STRAND BREAKS
- Descriptors DEC
- BIOLOGICAL RECOVERY; BODY; DIGESTIVE SYSTEM; DRUGS; ENZYMES; GLANDS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; OXIDOREDUCTASES; RESPONSE MODIFYING FACTORS
Optional Information
- Notes
- For English translation see the journal Radiobiology (Translation) (USA).