Compounds for site-enhanced delivery of radionuclides and uses thereof
Creators
Description
A dihydropyridine ↔ pyridinium salt type of redox, or chemical, delivery system for the site-specific and/or site-enhanced delivery of a radionuclide to the brain is provided. A chelating agent capable of chelating with a radionuclide and having a reactive hydroxyl, carboxyl, amino, amide or imide group is coupled to a carrier moiety comprising a dihydropyridine ↔ pyridinium salt nucleus and then complexed with a radionuclide to provide a new radiopharmaceutical that, in its lipoidal dihydropyridine form, penetrates the blood-brain barrier ('BBB') and allows increased levels of radionuclide concentration in the brain, particularly since oxidation of the dihydropyridine carrier moiety in vivo to the ionic pyridinium salt retards elimination from the brain while elimination from the general circulation is accelerated. This radionuclide delivery system is well suited for use in scintigraphy and similar radiographic techniques
Availability note (English)
Available from the Patents Office, Private Bag X400, Pretoria, 0001, South Africa.Additional details
Publishing Information
- Imprint Pagination
- 259 p.
- IPC:
- Int. Cl. C 07 D; A 61 K; A 61 M.
- IPC
- Int. Cl. C 07 D; A 61 K; A 61 M.
- Patent number
- ZA patent document 85/5476/A/
INIS
- Country of Publication
- South Africa
- Country of Input or Organization
- South Africa
- INIS RN
- 18055129
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Non-conventional Literature
- Descriptors DEI
- AMIDES; BIOMEDICAL RADIOGRAPHY; BRAIN; CARRIERS; CHELATING AGENTS; IMIDES; IN VIVO; PYRIDINIUM COMPOUNDS; RADIOISOTOPES; RADIOPHARMACEUTICALS; SCINTISCANNING
- Descriptors DEC
- AMINES; AZINES; BODY; CENTRAL NERVOUS SYSTEM; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DRUGS; HETEROCYCLIC COMPOUNDS; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MEDICINE; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIDINES; QUATERNARY COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING
Optional Information
- Secondary number(s)
- US priority 632,314.