Cell cycle dependent repair of potentially lethal heavy-ion damage

The authors have demonstrated a qualitative and quantitative difference in the response of synchronized human G1-phase cell populations to single doses of low-or high-LET radiation. They also have evidence that G1-cell populations that can repair x-ray-induced PLD are unable to effectively repair heavy-ion-induced PLD at early times in G1-phase but are capable of some repair in the late G1-phase. Treatment with an inhibitor of DNA polymerases (β-araA) can eliminate the PLDR observed after exposure to a single dose of either radiation quality