Published 1991 | Version v1
Journal article Metadata-only

Synthesis and radiation dosimetry of 4-borono-2-[18F]fluoro-D, L-phenylalanine: a target compound for PET and boron neutron capture therapy

Creators

  • 1. Tohoku Univ., Sendai (Japan)
  • 2. Kobe Univ. (Japan). School of Medicine

Description

The 18F-labeling of 4-borono-D-L-phenylalanine (BPA), a potential target compound for cancer treatment with boron neutron capture therapy, is described. By direct fluorination of BPA with [18F]AcOF or [18F]F2 followed by HPLC separation, 4-borono-2-[18F]fluoro-D,L-phenylalanine was prepared with radiochemical yields of 25-35% and with a radiochemical purity of over 99%. The tissue distribution study showed that the compound has potential as a tracer for pancreas imaging with positron emission tomography. Radiation dosimetry is also described. (author)

Additional details

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
42
Journal Issue
4
Series
Appl. Radiat. Isot.
Journal Page Range
325-328
ISSN
0883-2889
CODEN
ARISE

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
22049728
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BORON COMPLEXES; CHEMICAL PREPARATION; DOSIMETRY; FLUORINE 18; LABELLING; NEUTRON CAPTURE THERAPY; PHENYLALANINE; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; TRACER TECHNIQUES
Descriptors DEC
AMINO ACIDS; AROMATICS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; COMPLEXES; DISTRIBUTION; DRUGS; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MEDICINE; NANOSEC LIVING RADIOISOTOPES; NEUTRON THERAPY; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOTHERAPY; SYNTHESIS; THERAPY