Published January 1979 | Version v1
Journal article Metadata-only

Studies of the activity of cytosol on the mixed disulfide bond formed by proteins and radioprotector mercaptoethylguanidine

Creators

  • 1. National Inst. of Oncology, Budapest (Hungary)
  • 2. Orszagos Onkologiai Intezet, Budapest (Hungary)

Description

The cytoplasm of normal and tumorous rat liver cells contains a heat-resistant compound with reducing ability to break the mixed disulfide bond of albumin-14C-mercaptoethylguanidine. The reducing activity of cytosol is destoryed by 1000 krd 60Co-gamma-ray doses in diluted solution. In vivo supralethal of rats does not affect the activity of cytosol prepared from liver cells. (orig.)

Abstract (German)

Leberzellen normaler und tumortragender Ratten enthalten hitzebestaendiges Material (Cytosol) mit reduzierender Aktivitaet, das die gemischte Disulfidbruecke von Albumin-14C-mercaptoaethylguanidin aufzubrechen vermag. Die reduzierende Aktivitaet des Cytosol wird durch 1000 krd 60Co-Gammadosen in verduennter Loesung zerstoert. In vivo supraletale Bestrahlung der Ratten vermag die Aktivitaet des aus Rattenleberzellen gewonnen Cytosols nicht zu beeinflussen. (orig.)

Additional details

Publishing Information

Journal Title
Strahlentherapie
Journal Volume
155
Journal Issue
1
Series
Strahlentherapie.
Journal Page Range
63-66

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
10452127
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ANIMAL CELLS; BIOLOGICAL RADIATION EFFECTS; CELL CONSTITUENTS; CHEMICAL BONDS; CYTOPLASM; GAMMA RADIATION; INHIBITION; LIVER; MEG; PROTEINS; RATS; REDUCTION; SUPRALETHAL IRRADIATION
Descriptors DEC
ANIMALS; BIOLOGICAL EFFECTS; BODY; CARBONIC ACID DERIVATIVES; CHEMICAL REACTIONS; DIGESTIVE SYSTEM; DRUGS; ELECTROMAGNETIC RADIATION; GLANDS; IONIZING RADIATIONS; IRRADIATION; MAMMALS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; THIOLS; VERTEBRATES