Exploration of D2 receptors and content of DA of striatum in hemi-parkinsonism model rats before and after madopar treatment
Description
125I-IBZM autoradiographic analysis, HPLC-ECD were used to study the relationship between D2 receptors and the content of DA, HVA, DOPAC in striatum of hemi-parkinsonism model rats before and after Madopar treatment. After Madopar treatment, the striatum/cerebellum 125I-IBZM uptake ratio of lesioned side was 7.23 +- 0.67, showed 17.22 +- 3.94% increasing as compared to the contralateral side, the increasing were significantly declined compared with the pretreatment group and control group (P<0.01). The DA, HVA, DOPAC levels in lesioned side striatum of Madopar group were increased compared with the other two groups (P<0.05). All of the above verified that Madopar treatment can elevate DA levels of lesioned striatum in hemi-parkinsonism model rats, and thus prevent and reverse the up-regulation of D2 receptors
Additional details
Publishing Information
- Journal Title
- Nuclear Techniques
- Journal Volume
- 21
- Journal Issue
- 5
- Journal Page Range
- p. 257-261
- ISSN
- 0253-3219
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 29044194
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- AMIDES; BRAIN; DIAGNOSIS; DOPAMINE; IMAGES; IODINE 125; LABELLING; LIQUID COLUMN CHROMATOGRAPHY; METABOLITES; NERVOUS SYSTEM DISEASES; RADIOISOTOPE SCANNING; RADIOPHARMACEUTICALS; RATS; RECEPTORS; THERAPY
- Descriptors DEC
- AMINES; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BODY; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; CHROMATOGRAPHY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MEDICINE; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SEPARATION PROCESSES; SYMPATHOMIMETICS; VERTEBRATES