Published March 2009 | Version v1
Journal article Metadata-only

Cell survival and chromosomal aberrations in CHO-K1 cells irradiated by carbon ions

Creators

  • 1. Institute of Physics, Swietokrzyska Academy, ul. Swietokrzyska 15, 25-406 Kielce (Poland)
  • 2. Holycross Cancer Center, ul. Swietokrzyska 15, 25-406 Kielce (Poland)
  • 3. Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, Grudziadzka 5, 87-100 Torun (Poland)
  • 4. Institute of Nuclear Chemistry and Technology, ul. Dorodna 16, 03-195 Warsaw (Poland)
  • 5. Heavy Ion Laboratory, Warsaw University, ul. Pasteura 5A, 02-093 Warsaw (Poland)
  • 6. Institute of Experimental Physics, Warsaw University, ul. Hoza 69, 00-681 Warsaw (Poland)
  • 7. Andrzej Soltan Institute for Nuclear Studies, 05-400 Otwock-Swierk (Poland)
  • 8. Institute of Biology, Swietokrzyska Academy, ul. Swietokrzyska 15, 25-406 Kielce (Poland)
  • 9. Main School of Fire Service, ul. Slowackiego 52/54, 01-629 Warsaw (Poland)

Description

Chinese hamster ovary CHO-K1 cells were exposed to high LET 12C-beam (LET: 830 keV/μm) in the dose range of 0-6 Gy and to 60Co irradiation and the RBE value was obtained. Effects of 12C-beam exposure on cell survival and chromosomal aberrations were calculated. The chromosomal aberration data were fitted with linear equation. The distribution of aberration in cells was examined with a standard u-test and used to evaluate the data according to Poisson probabilities. The variance to the mean ratio σ2/Y and the dispersion index (u) were determined. Overdispersion was significant (p<0.05) when the value of u exceeded 1.96

Availability note (English)

Available from http://dx.doi.org/10.1016/j.apradiso.2008.06.016

Additional details

Identifiers

DOI
10.1016/j.apradiso.2008.06.016;
PII
S0969-8043(08)00334-5;

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
67
Journal Issue
3
Journal Page Range
p. 447-453
ISSN
0969-8043
CODEN
ARISEF

Conference

Title
1. international conference on biomedical applications of high energy ion beams
Dates
30 Jul - 2 Aug 2007
Place
Surrey (United Kingdom)

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
40045607
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BEAMS; CARBON 12; CARBON IONS; CHROMOSOMAL ABERRATIONS; COBALT 60; HAMSTERS; IRRADIATION; KEV RANGE 100-1000; LET; OVARIES; RADIATION DOSES
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBON ISOTOPES; CHARGED PARTICLES; COBALT ISOTOPES; DOSES; ENERGY RANGE; ENERGY TRANSFER; EVEN-EVEN NUCLEI; FEMALE GENITALS; GONADS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KEV RANGE; LIGHT NUCLEI; MAMMALS; MINUTES LIVING RADIOISOTOPES; MUTATIONS; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIOISOTOPES; RODENTS; STABLE ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Copyright
Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.