Tumor xenotransplantation in Wistar rats after treatment with cyclophosphamide and total lymphoid irradiation
Creators
- 1. St. Radbond Academic Hospital, Nijmegen, Netherlands
Description
Three-month-old male Wistar rats were treated with cyclophosphamide and total lymphoid irradiation, and C22LR mouse osteosarcoma was transplanted into the rats. The effects of immunosuppression were monitored by lymphocyte counts, serum IgG determinations, phytohemagglutinin (PHA) and concanavalin A (Con A) responses, measurement of the proportion of B cells, and histopathological studies of the lymphoid organs. At eight days after treatment, the lymphocyte counts, IgG levels, and PHA and Con A values were decreased. Mitotic activity started in the depleted B and T cell areas of the peripheral lymphatic organs two weeks after treatment. There was a 94% graft take of the osteosarcoma. It was determined that the optimum time for tumor xenograft transplantation is 4 days after treatment. The duration of growth was 11 days, and this was followed by regression up to day 21
Additional details
Additional titles
- Augmented title (English)
- X-ray
Publishing Information
- Journal Title
- Radiology
- Journal Volume
- 145
- Journal Issue
- 1
- Series
- Radiology.
- Journal Page Range
- 191-194
- ISSN
- 0033-8419
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 14741875
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- DOSE-RESPONSE RELATIONSHIPS; ENDOXAN; EXPERIMENTAL NEOPLASMS; IMMUNOSUPPRESSION; LYMPH NODES; PARTIAL BODY IRRADIATION; RADIATION EFFECTS; RATS; TRANSPLANTS; X RADIATION
- Descriptors DEC
- ALKYLATING AGENTS; ANIMALS; ANTIMITOTIC DRUGS; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; IONIZING RADIATIONS; IRRADIATION; LYMPHATIC SYSTEM; MAMMALS; NEOPLASMS; RADIATIONS; RODENTS; VERTEBRATES