A stochastic approach to multi-gene expression dynamics
Creators
- 1. Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji 611-0011 (Japan)
Description
In the last years, tens of thousands gene expression profiles for cells of several organisms have been monitored. Gene expression is a complex transcriptional process where mRNA molecules are translated into proteins, which control most of the cell functions. In this process, the correlation among genes is crucial to determine the specific functions of genes. Here, we propose a novel multi-dimensional stochastic approach to deal with the gene correlation phenomena. Interestingly, our stochastic framework suggests that the study of the gene correlation requires only one theoretical assumption-Markov property-and the experimental transition probability, which characterizes the gene correlation system. Finally, a gene expression experiment is proposed for future applications of the model
Additional details
Identifiers
- DOI
- 10.1016/j.physleta.2005.02.066;
- arXiv
- arXiv:q-bio/0502015v2;
- PII
- S0375-9601(05)00374-9;
Publishing Information
- Journal Title
- Physics Letters. A
- Journal Volume
- 339
- Journal Issue
- 1-2
- Journal Page Range
- p. 1-9
- ISSN
- 0375-9601
- CODEN
- PYLAAG
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 37034022
- Subject category
- S71: CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- CORRELATIONS; GENES; MARKOV PROCESS; MOLECULES; PROBABILITY; PROTEINS; RNA
- Descriptors DEC
- NUCLEIC ACIDS; ORGANIC COMPOUNDS; STOCHASTIC PROCESSES
Optional Information
- Copyright
- Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.