Published May 16, 2005 | Version v1
Journal article

A stochastic approach to multi-gene expression dynamics

  • 1. Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji 611-0011 (Japan)

Description

In the last years, tens of thousands gene expression profiles for cells of several organisms have been monitored. Gene expression is a complex transcriptional process where mRNA molecules are translated into proteins, which control most of the cell functions. In this process, the correlation among genes is crucial to determine the specific functions of genes. Here, we propose a novel multi-dimensional stochastic approach to deal with the gene correlation phenomena. Interestingly, our stochastic framework suggests that the study of the gene correlation requires only one theoretical assumption-Markov property-and the experimental transition probability, which characterizes the gene correlation system. Finally, a gene expression experiment is proposed for future applications of the model

Additional details

Identifiers

DOI
10.1016/j.physleta.2005.02.066;
arXiv
arXiv:q-bio/0502015v2;
PII
S0375-9601(05)00374-9;

Publishing Information

Journal Title
Physics Letters. A
Journal Volume
339
Journal Issue
1-2
Journal Page Range
p. 1-9
ISSN
0375-9601
CODEN
PYLAAG

INIS

Country of Publication
Netherlands
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
37034022
Subject category
S71: CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; S60: APPLIED LIFE SCIENCES;
Descriptors DEI
CORRELATIONS; GENES; MARKOV PROCESS; MOLECULES; PROBABILITY; PROTEINS; RNA
Descriptors DEC
NUCLEIC ACIDS; ORGANIC COMPOUNDS; STOCHASTIC PROCESSES

Optional Information

Copyright
Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.