Published June 1963 | Version v1
Miscellaneous Open

Daily and hourly kinetics of the transformation of 26 - 14C cholesterol into bile acids

Creators

Description

The measurement of the rate of transformation of cholesterol into bile acids has been undertaken by a new method. At isotopic equilibrium, the quantity of 14CO2 exhaled by a rat being constant, the determination of the specific radioactivity of mobile cholesterol allows the calculation of the mass of cholesterol transformed daily into bile acids. The various techniques used are described and the obtained quantitative results discussed. When the rats ingest their meal at fixed times, it is found that the daily kinetics of the transformation is not linked to the nycthemeral rhythm, but is linked to the rhythm of the digestive functions

Abstract (French)

La mesure de la vitesse de transformation du cholesterol en acides biliaires a ete entreprise par une nouvelle methode. A l'equilibre isotopique, la quantite de 14CO2 expire par un rat etant constante, la determination de la radioactivite specifique du cholesterol mobile permet le calcul de la masse de cholesterol transforme quotidiennement en acides biliaires. Les diverses techniques utilisees sont decrites et les resultats quantitatifs obtenus discutes. Lorsque les rats ingerent leur repas a des heures fixes, on constate que la cinetique quotidienne de la transformation n'est pas liee au rythme nycthemeral, mais est liee au rythme des fonctions digestives. (auteur)

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Additional details

Additional titles

Original title (French)
Cinetiques journaliere et horaire de la transformation du cholesterol 26 - 14C en acides biliaires

Publishing Information

Imprint Pagination
52 p.
Report number
INIS-FR--23-0130

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
54020442
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S60: APPLIED LIFE SCIENCES;
Resource subtype / Literary indicator
Thesis
Descriptors DEI
ACTIVITY LEVELS; BILE; BILE ACIDS; BIOCHEMICAL REACTION KINETICS; BREATH; CARBON 14; CARBON DIOXIDE; CHOLESTEROL; DIGESTIVE SYSTEM; EXHALATION; MEASURING METHODS; METABOLISM; RADIOACTIVITY; RADIOPHARMACEUTICALS; RATS; TRACER TECHNIQUES
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BODY FLUIDS; CARBON COMPOUNDS; CARBON ISOTOPES; CARBON OXIDES; CARBOXYLIC ACIDS; CHALCOGENIDES; CLEARANCE; DRUGS; EVEN-EVEN NUCLEI; EXCRETION; HYDROXY COMPOUNDS; ISOTOPE APPLICATIONS; ISOTOPES; KINETICS; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MATERIALS; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; OXIDES; OXYGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; REACTION KINETICS; RODENTS; STEROIDS; STEROLS; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
38 refs.; Available from the INIS Liaison Officer for France, see the INIS website for current contact and E-mail addresses