Published 1989 | Version v1
Journal article Metadata-only

Improvement of the reproducibility of ion-pair HPLC of 99mTc(Sn)EHDP complexes and the influence of the Sn(II) concentration on the composition of the reaction mixture

Creators

  • 1. Netherlands Energy Research Foundation, Petten
  • 2. Rijksuniversiteit Utrecht (Netherlands). Analytisch Chemisch Lab.

Description

The use of a non-volatile modifier and the simultaneous exclusion of oxygen by flushing with helium in ion-pair HPLC of 99mTc(Sn)EHDP-complexes prevents spurious oxidation during the separation process. It thus enables the omission of the reducing agent from the eluent solution and the determination of the labelling percentage from the TcO41-peak. In addition, retention times become more reproducible. (author)

Additional details

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
40
Journal Issue
2
Series
Appl. Radiat. Isot.
Journal Page Range
153-157
CODEN
ARISE

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
20028816
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
CHELATING AGENTS; LABELLING; LIQUID COLUMN CHROMATOGRAPHY; RADIOPHARMACEUTICALS; REDUCTION; TECHNETIUM COMPLEXES; TECHNETIUM 99
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHEMICAL REACTIONS; CHROMATOGRAPHY; COMPLEXES; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; RADIOACTIVE MATERIALS; RADIOISOTOPES; SEPARATION PROCESSES; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPLEXES; YEARS LIVING RADIOISOTOPES