Published 1991 | Version v1
Journal article Metadata-only

Some biochemical aspects of the protective effect of strontium chloride on gamma-irradiated rats

Creators

  • 1. Ain Shams Univ., Cairo (Egypt). Dept. of Biochemistry
  • 2. National Centre for Radiation Research and Technology, Cairo (Egypt)

Description

The effect of treatment with SrCl2 (10 mg/100 g rat) on rats 15 minutes prior to whole body γ-irradiation (7,5 Gy) was studied. The hazardeous effects of irradiation were greatly corrected in the treated group. The hyperglycemic effect and liver glycogen accumulation in the untreated group decreased to normal level. The enzymatic activities of serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase und lactate dehydrogenase were greatly affected showing insignificant changes in the treated group of animals. Life span calculated on 50% survival was also significantly elongated by 36.3%. These results show the potentiality of SrCl2 as a radioprotective agent which was not used before. (orig.)

Abstract (German)

Es wurde die Wirkung von SrCl2 (10 mg/100 g Koerpergewicht) auf Ratten untersucht, die 15 Minuten lang einer Ganzkoerperbestrahlung mit γ-Strahlen (7,5 Gy) behandelt wurden. Die gefaehrlichen Strahlenauswirkungen wurden groesstenteils bei der behandelten Gruppe behoben. Der hyperglykaemische Effekt und die Akkumulation von Glycogen in der Leber nahm bei der behandelten Gruppe auf Normalwerte ab. Die Enzymaktivitaeten von alkalischer Phoshatase, Alanin-Aminotransferase, Aspartat-Aminotransferase und Lactat-Dehydrogenase wurden groesstenteils beeinflusst, wobei keine signifikanten Veraenderungen bei der behandelten Gruppe zu sehen waren. Die Lebensdauer, berechnet auf 50% Ueberlebenszeit, war ebenfalls signifikant auf 36.3% verlaengert. Diese Ergebnisse zeigen die Moeglichkeit von SrCl2 als Wirkstoff fuer den Strahlenschutz auf, der bisher nicht eingesetzt wurde. (orig.)

Additional details

Publishing Information

Journal Title
Isotopenpraxis
Journal Volume
27
Journal Issue
7
Series
Isotopenpraxis.
Journal Page Range
318-324
ISSN
0021-1915
CODEN
IPRXA

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
23021815
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ALKALINE PHOSPHATASE; AMINOTRANSFERASES; BIOCHEMISTRY; BIOLOGICAL RADIATION EFFECTS; EFFICIENCY; ENZYME ACTIVITY; GAMMA RADIATION; GLYCOGEN; HYPERGLYCEMIA; LACTATE DEHYDROGENASE; LIVER; RADIOPROTECTIVE SUBSTANCES; RATS; STRONTIUM CHLORIDES; SURVIVAL CURVES; SURVIVAL TIME; WHOLE-BODY IRRADIATION
Descriptors DEC
ALKALINE EARTH METAL COMPOUNDS; ANIMALS; BIOLOGICAL EFFECTS; BODY; CARBOHYDRATES; CHEMISTRY; CHLORIDES; CHLORINE COMPOUNDS; DEHYDROGENASES; DIGESTIVE SYSTEM; DRUGS; ELECTROMAGNETIC RADIATION; ENZYMES; ESTERASES; EXTERNAL IRRADIATION; GLANDS; HALIDES; HALOGEN COMPOUNDS; HYDROLASES; IONIZING RADIATIONS; IRRADIATION; MAMMALS; NITROGEN TRANSFERASES; ORGANIC COMPOUNDS; ORGANS; OXIDOREDUCTASES; PHOSPHATASES; POLYSACCHARIDES; PROTEINS; RADIATION EFFECTS; RADIATIONS; RESPONSE MODIFYING FACTORS; RODENTS; SACCHARIDES; STRONTIUM COMPOUNDS; TRANSFERASES; VERTEBRATES