Published June 1990
| Version v1
Journal article
Characterization of ROS1 cDNA from a human glioblastoma cell line
Creators
- 1. Max-Planck-Gesellschaft, Cologne (West Germany)
- 2. Cold Spring Harbor Laboratory, NY (USA)
Description
The authors have isolated and characterized a human ROS1 cDNA from the glioblastoma cell line SW-1088. The cDNA, 8.3 kilobases long, has the potential to encode a transmembrane tyrosine-specific protein kinase with a predicted molecular mass of 259 kDa. The putative extracellular domain of ROS1 is homologous to the extracellular domain of the sevenless gene product from Drosophila. No comparable similarities in the extracellular domains were found between ROS1 and other receptor-type tyrosine kinases. Together, ROS1 and sevenless gene products define a distinct subclass of transmember tyrosine kinases
Additional details
Publishing Information
- Journal Title
- Proceedings of the National Academy of Sciences of the United States of America
- Journal Volume
- 87
- Journal Issue
- 12
- Series
- Proc. Natl. Acad. Sci. U.S.A.
- Journal Page Range
- 4799-4803
- ISSN
- 0027-8424
- CODEN
- PNASA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 22043342
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- DNA SEQUENCING; GLIOMAS; MAN; ONCOGENES; PHOSPHOTRANSFERASES; PROTEIN STRUCTURE; PROTEINS; RECEPTORS; RECOMBINANT DNA; TUMOR CELLS; TYROSINE
- Descriptors DEC
- AMINO ACIDS; ANIMAL CELLS; ANIMALS; AROMATICS; CARBOXYLIC ACIDS; DISEASES; DNA; ENZYMES; GENES; HYDROXY ACIDS; MAMMALS; NEOPLASMS; NERVOUS SYSTEM DISEASES; NUCLEIC ACIDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; PHOSPHORUS-GROUP TRANSFERASES; PRIMATES; STRUCTURAL CHEMICAL ANALYSIS; TRANSFERASES; VERTEBRATES