Prognostic significance of clinico-pathological parameters in locally advanced bladder cancer

Organ preservation should be the main interest in the treatment of patients with locally advanced bladder cancer. The selection of patients for the respective therapy is mainly based on tumor staging, grading and multiplicity. In the present study data from 65 patients with locally advanced bladder tumors treated by an integrated chemo- radio-therapy were evaluated. The cytostatic drugs used were either Cisplatinium (19 patients (29,2 %))or Adriamycin (21 patients (32.3 %)) alone or a combination (25 patients (38,4 %)). Complete remission was achieved in 53 patients (81,5 %). The following parameters were investigated and evaluated for their prognostic significance in a multivariant analysis. 1.) Histology: tumorgrade, tumortype-papillary/solid, infiltration patterns, lymph and/or blood vessel invasion and areas of squamous cell differentiation within the tumor; 2.) Clinic: staging, tumor volume, multiplicity, therapy and hydronephrosis. The predictive value of these parameters in regard to the therapy response of the tumors was calculated. This study actually showed a statistically worse outcome for patients with papillary histology. All other parameters did not show any significance concerning the tumor remission in response to integrated radio-chemo-therapy. (author)