Carbon coated (Fe-Fe₃C) and Ag-doped lanthanum manganite (Ag_xLa_1-xMnO₃) nanocomposites for magnetic hypertermia of cancer cells

The presented research deals with two promising materials for cancer hyperthermia: ferromagnetic (Fe-Fe₃C)&C nanocomposites and carbon black-Ag_xLa_1-xMnO₃ hybrid nanocomposites. Carbon-coated (Fe-Fe₃C)&C nanocomposites were synthesized using the solid-phase pyrolysis (SPP) of metal-organic compounds in a wide range of experimental conditions (temperature, time and pressure in the reaction ampoule) resulting in various concentrations of Fe-Fe₃C core-shell. The ultrasound processing and size separation of nanoparticles have been made after synthesis of nanocomposites. The structure, morphology and magnetic characteristics of these nanocomposites were investigated by electron microscopy, X-ray diffraction, Raman spectroscopy and magneto-metric experiments. Ag-doped LaMnO₃ nanoparticles and modified carbon black were used to produce a hybrid nanocomposite. AgLaMnO₃ nanoparticles were synthesized using both the microwave enhances paper method and microwave combustion method. The morphology and magnetic characteristics of the modified carbon black-LaMnO₃ hybrid nanocomposites was characterized by electron microscopy, X-ray diffraction and magneto-metric experiments. Ag_xLa_1-xMnO₃ nanoparticles (after sintering at 300 ℃) were uniformly dispersed in the carbon matrix, which had a hollow quasi-spherical structure. All synthesized and studied materials proved to be very promising materials, while carbon black AgLaMnO₃ hybrid nanocomposites represented unique properties as materials for cancer hyperthermia with ''self-controlled'' working temperature in the range about 41 - 43 ℃. (author)