Published 1983 | Version v1
Book Metadata-only

Radiation protection of glutathion-deficient cells by thiol-containing compounds

Creators

Description

Results of the experiments on the effect of aminothiols (under conditions of hypoxia and in the air) on radiation injury of glutathion-deficient human fibroblasts (criterionthe number of single-strand breaks in DNA) have been interpreted in the following way protection with eddogenous and exogenous aminothiols takes place to a great extent due to repair of radiation induced radicals by means of hydrogen loss by SH-group under conditions of competition with oxygen which registers the radiation injury. Repair of in uries formed under aeration conditions is accelerated by endogenoUs and exogenous aminothiols

Additional details

Additional titles

Original title (Russian)
Защита от облучения глютатион-дефицитных клеток тиолсодержащими соединениями

Publishing Information

Publisher
Nauka.
Imprint Place
Moscow (USSR)
Imprint Title
The problems of natural and modifyed radiosensitivity
Journal Page Range
p. 220-226.

INIS

Country of Publication
USSR
Country of Input or Organization
USSR
INIS RN
16013609
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ANOXIA; BIOLOGICAL REPAIR; DNA; FIBROBLASTS; GLUTATHIONE; MAN; RADIOPROTECTIVE SUBSTANCES; STRAND BREAKS; THIOLS; X RADIATION
Descriptors DEC
ANIMAL CELLS; ANIMALS; BIOLOGICAL RECOVERY; CONNECTIVE TISSUE CELLS; DRUGS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; MAMMALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PEPTIDES; POLYPEPTIDES; PRIMATES; PROTEINS; RADIATIONS; RESPONSE MODIFYING FACTORS; SOMATIC CELLS; VERTEBRATES

Optional Information

Notes
26 refs.; 2 tabs. Imprint:Problemy prirodnoj i modifitsirovannoj radiochuvstvitel'nosti.