Published May 2011 | Version v1
Journal article Metadata-only

Association between single nucleotide polymorphisms in the DNA repair gene LIG3 and acute adverse skin reactions following radiotherapy

Creators

  • 1. Department of Genetics, University of Leicester (United Kingdom)
  • 2. Department of Cancer Studies and Molecular Medicine, University Hospitals of Leicester (United Kingdom)
  • 3. Department of Clinical Oncology, Nottingham University Hospitals NHS Trust (City Hospital Campus) (United Kingdom)
  • 4. Department of Clinical Oncology, Derby Hospitals NHS Foundation Trust (United Kingdom)

Description

Many genes have been associated with radiotherapy toxicity, but most have only been found in a single study. Using our cohort of 480 breast cancer patients, we provide replicated evidence that a polymorphism near the LIG3 gene is associated with acute skin toxicity following radiotherapy.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.radonc.2011.05.007

Additional details

Identifiers

DOI
10.1016/j.radonc.2011.05.007;
PII
S0167-8140(11)00199-X;

Publishing Information

Journal Title
Radiotherapy and Oncology
Journal Volume
99
Journal Issue
2
Journal Page Range
p. 231-234
ISSN
0167-8140
CODEN
RAONDT

INIS

Country of Publication
Ireland
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
43064847
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
DNA REPAIR; GENES; GENETICS; MAMMARY GLANDS; NEOPLASMS; NUCLEOTIDES; PATIENTS; RADIOTHERAPY; SKIN; TOXICITY
Descriptors DEC
BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; BIOLOGY; BODY; DISEASES; GLANDS; MEDICINE; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANS; RADIOLOGY; REPAIR; THERAPY

Optional Information

Copyright
Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.