Published September 2017 | Version v1
Journal article Metadata-only

Composite cutaneous lymphoma (iatrogenic immunodeficiency-associated lymphoproliferative disorder) in a patient with rheumatoid arthritis treated with methotrexate: Staging and evaluation of response to therapy with 1'8F-FDG PET/CT

Creators

  • 1. Dept. of Diagnostic Imaging, CCI, Diagnostic Imaging, Edmonton (Canada)
  • 2. MUHC Glen Site, Montreal (Canada)
  • 3. MUHC, Dermatology, Westmount (Canada)
  • 4. MUHC Jewish General Hospital, Nuclear Medicine, Montreal (Canada)

Description

A 67 year old woman with a 10 year history of rheumatoid arthritis (RA) treated with methotrexate and prednisone, presented with a 2 year history of worsening multiple cutaneous plaques of variable appearance. Two distinct skin lesions were biopsied to reveal a composite cutaneous lymphoma, possibly caused by long term methotrexate therapy. An [18F] fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) was performed to stage the malignancy, and was later repeated to evaluate response to chemotherapy, which guided subsequent management. We present the PET/CT imaging findings of this very rare iatrogenic (methotrexate induced) immunodeficiency-associated lymphoproliferative disorder

Additional details

Publishing Information

Journal Title
Nuclear Medicine and Molecular Imaging (2010 Print)
Journal Volume
51
Journal Issue
3
Series
17 refs, 4 figs
Journal Page Range
p. 261-265
ISSN
1869-3474

INIS

Country of Publication
Germany
Country of Input or Organization
Korea, Republic of
INIS RN
48090100
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BIOPSY; IMMUNOLOGY; PATIENTS; PERFORMANCE; POSITRON COMPUTED TOMOGRAPHY; RHEUMATIC DISEASES; SKIN; THERAPY
Descriptors DEC
BODY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; EMISSION COMPUTED TOMOGRAPHY; MEDICINE; ORGANS; TOMOGRAPHY