Published February 2005 | Version v1
Journal article Metadata-only

Analysis of proteomic changes of the serum of irradiated mice

Creators

  • 1. Academy of Mitiary Medical Sciences, Beijing (China). Inst. of Radiation Medicine

Description

To explore the early diagnostic factors, new therapeutic targets and mechanisms of acute radiation disease. Proteomic changes of the serum of irradiated mice were studied using 2-DE and Q-TOF-MS approaches. One higher level expressed protein after the irradiation was found, and it was identified as α chain of haptoglobin by Q-TOF-MS. The authors confirmed the result by Western blotting with anti-haptoglobin antibody. Haptoglobin may involve in the process of acute radiation injury. (authors)

Additional details

Publishing Information

Journal Title
Journal of Radiation Research and Radiation Processing
Journal Volume
23
Journal Issue
1
Journal Page Range
p. 53-56
ISSN
1000-3436

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
37089539
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ACUTE IRRADIATION; AMINO ACID SEQUENCE; BENCH-SCALE EXPERIMENTS; BLOOD SERUM; DOSE-RESPONSE RELATIONSHIPS; EARLY RADIATION EFFECTS; ELECTROPHORESIS; HAPTOGLOBINS; MICE; PROTEINS; RADIATION INJURIES
Descriptors DEC
ACUTE EXPOSURE; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD PLASMA; BODY FLUIDS; CARBOHYDRATES; DISEASES; GLOBULINS; GLOBULINS-ALPHA; INJURIES; IRRADIATION; MAMMALS; MATERIALS; MOLECULAR STRUCTURE; MUCOPROTEINS; ORGANIC COMPOUNDS; POLYSACCHARIDES; PROTEINS; RADIATION EFFECTS; RODENTS; SACCHARIDES; VERTEBRATES

Optional Information

Notes
3 figs., 8 refs.