Published 2015 | Version v1
Journal article Metadata-only

Synthesis and structural properties of Polyvinylpyrrolidone based nanocomposite hydrogels for isoniazid drug delivery

Creators

  • 1. Young Researchers and Elite Club, Farahan Branch, Islamic Azad University, Farahan (Iran, Islamic Republic of)
  • 2. Department of Chemical Engineering, Farahan Branch, Islamic Azad University, Farahan (Iran, Islamic Republic of)

Description

In this study, several examples of hydrogels and nanocomposite hydrogels based on PVP with different content of montmorillonite nanoclay were prepared. Then, the swelling of hydrogels and kinetics of drug delivery of hydrogel in an environment similar to the body (pH 7.4) were examined. The effect of nanoparticle different percentages on the hydrogel was clearly observed. Then kinetics of drug (Isoniazid) delivery for various samples of hydrogel with nanoparticles and without nanoparticles were obtained via Peppas and Higuchi models. The comparison of Peppas model results with experimental data showed that nanocomposite with 4% nanoclay exhibited better compliance. The morphology and microstructure of the prepared nanocomposites were studied by FT-IR, XRD and SEM.

Availability note (English)

Available from http://jpst.irost.ir/article_263_0e67549082a0feb9ead10f889fea31e1.pdf; https://doaj.org/article/37a4b6bdb1f44ef2ac9ced4a35b27c2e

Additional details

Identifiers

URL
http://jpst.irost.ir/article_263_0e67549082a0feb9ead10f889fea31e1.pdf; https://doaj.org/article/37a4b6bdb1f44ef2ac9ced4a35b27c2e;
DOI
10.22104/jpst.2015.263;

Publishing Information

Journal Title
Journal of Particle Science and Technology
Journal Volume
1
Journal Issue
3
Journal Page Range
p. 183-193
ISSN
2423-4087

INIS

Country of Publication
Iran, Islamic Republic of
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
51037348
Subject category
S77: NANOSCIENCE AND NANOTECHNOLOGY;
Descriptors DEI
DRUG DELIVERY; INFRARED SPECTRA; ISONIAZID; MICROSTRUCTURE; MONTMORILLONITE; MORPHOLOGY; NANOCOMPOSITES; NANOPARTICLES; PVP; SCANNING ELECTRON MICROSCOPY; SWELLING; X-RAY DIFFRACTION
Descriptors DEC
AMIDES; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL AGENTS; AZOLES; BLOOD SUBSTITUTES; CLAYS; COHERENT SCATTERING; DEFORMATION; DIFFRACTION; DRUGS; ELECTRON MICROSCOPY; HEMATOLOGIC AGENTS; HETEROCYCLIC COMPOUNDS; HYDRAZIDES; INORGANIC ION EXCHANGERS; ION EXCHANGE MATERIALS; LACTAMS; MATERIALS; MICROSCOPY; MINERALS; NANOMATERIALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC POLYMERS; PARTICLES; POLYMERS; POLYVINYLS; PYRROLES; PYRROLIDONES; SCATTERING; SILICATE MINERALS; SPECTRA