Published November 28, 1983
| Version v1
Journal article
Striatal dopamine metabolism in living monkeys examined by positron emission tomography
Creators
- 1. McMaster University Medical Centre, Hamilton, Ontario (Canada). Dept. of Nuclear Medicine
Description
Positron emission tomography, using the dopa analogue [18F]6-fluoro-L-dopa, has been used to depict the neostriatum in living monkeys. The amount of 18F that accumulated preferentially in the striatum could be augmented by a peripheral decarboxylase inhibitor. Striatal 18F could also be discharged with reserpine. This is the first time that the regional distribution of a neurotransmitter has been demonstrated in monkeys. (Auth.)
Additional details
Publishing Information
- Journal Title
- Brain Res.
- Journal Volume
- 280
- Journal Issue
- 1
- Series
- Brain Res.
- Journal Page Range
- 169-171
- ISSN
- 0006-8993
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- Netherlands
- INIS RN
- 15027839
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BIOLOGICAL LOCALIZATION; BRAIN; DOPA; FLUORINE 18; IN VIVO; INTRAVENOUS INJECTION; LABELLED COMPOUNDS; METABOLISM; MONKEYS; POSITRON COMPUTED TOMOGRAPHY
- Descriptors DEC
- AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROXY ACIDS; INJECTION; INTAKE; ISOTOPES; LIGHT NUCLEI; MAMMALS; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PRIMATES; RADIOISOTOPES; TOMOGRAPHY; VERTEBRATES