Application of fractional uptake method to 99mTc-ECD SPECT for quantification of brain perfusion using cardiac output index
- 1. Kobe Univ. (Japan). School of Medicine
Description
Fractional uptake (FU) method, which was originally designed for 123I-IMP (123I-N-isopropyl-p-iodoamphetamine) SPECT, was modified and applied for measuring cerebral blood flow (CBF) using 99mTc-ECD (99mTc-ethyl-cysteinate dimer) SPECT. FU method uses the value of cardiac output (CO) calculating from the body surface area of patients. However this CO is not precise enough to reflect real CBF. Using 99mTc-ECD we calculated cardiac output index (COI) according to the regression line of CO measured with 99mTc-RBC (99mTc-Red Blood Cell) and 131I-HSA (131I-Human Serum Albumin) in 10 patients. The present studies revealed that the mean CBF values calculated by this method were larger than those measured by other previously reported methods. (author)
Additional details
Publishing Information
- Journal Title
- Kobe Daigaku Igakubu Kiyo
- Journal Volume
- 58
- Journal Issue
- 4
- Journal Page Range
- p. 191-196
- ISSN
- 0075-6431
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 29037544
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BENZEDRINE; BLOOD FLOW; COMPARATIVE EVALUATIONS; CYSTEINE; DIMERS; IODINE 123; IODINE 131; SCINTISCANNING; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; TECHNETIUM 99; UPTAKE
- Descriptors DEC
- AMINES; AMINO ACIDS; AMPHETAMINES; ANALEPTICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM AGENTS; COMPUTERIZED TOMOGRAPHY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; EVALUATION; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SYMPATHOMIMETICS; TECHNETIUM ISOTOPES; THIOLS; TOMOGRAPHY; YEARS LIVING RADIOISOTOPES