Photocatalytic degradation of ketoconazole by Z-scheme Ag₃PO₄/graphene oxide: response surface modeling and optimization

Ketoconazole is an imidazole fungicide which is commonly used as pharmaceutical and healthcare products. Residual amount of this compound can cause adverse ecological health problems. The present study investigated ketoconazole photocatalytic degradation using Ag₃PO₄/graphene oxide (GO). Ag₃PO₄/GO and Ag₃PO₄ as visible light-driven photocatalysts was synthesized using the in situ growth method. Degradation of ketoconazole at the concentration of 1–20 mg/L in aqueous solutions was optimized in the presence of Ag₃PO₄/GO nanocomposite with the dosage of 0.5–2 g/L, contact time of 15–20 min, and pH of 5–9 using response surface methodology. A second-order model was selected as the best fitted model with R² value and lack of fit as 0.935 and 0.06, respectively. Under the optimized conditions, the Ag₃PO₄/GO catalyst achieved a photocatalytic efficiency of 96.53% after 93.34 min. The photocatalytic activity, reaction kinetics, and stability were also investigated. The results indicated that the Ag₃PO₄/GO nanocomposite exhibited higher photocatalytic activity for ketoconazole degradation, which was 2.4 times that of pure Ag₃PO₄. Finally, a direct Z-scheme mechanism was found to be responsible for enhanced photocatalytic activity in the Ag₃PO₄/GO nanocomposite. The high photocatalytic activity, acceptable reusability, and good aqueous stability make the Ag₃PO₄/GO nanocomposite a promising nanophotocatalyst for photocatalytic degradation of azoles contaminants.