Published February 2003
| Version v1
Journal article
Influence of binding characteristics of 153Sm-complexes to BSA on their bone uptake
- 1. China Academy of Engineering Physics, Mianyang (China). Inst. of Nuclear Physics and Chemistry
Description
The bone uptake in normal mice and adsorption on bone model materials (hydroxyapatite and type I collagen) of 153Sm-NTMP, 153Sm-HEDTMP, 153Sm-DCTMP, 153Sm-EDTMP, 153Sm-DTPMP and 153Sm-DTPA are compared, and then the binding characteristics of these 153Sm-complexes to bovine serum albumin (BSA) are investigated. It is found that there is a discrepancy between the bone uptake and the adsorption on bone model materials, and that the binding characteristics of these 153Sm-complexes to BSA play an important role in the process of their bone uptake. Also, the binding characteristics are applied to explain the discrepancy successfully
Additional details
Publishing Information
- Journal Title
- Journal of Nuclear and Radiochemistry
- Journal Volume
- 25
- Journal Issue
- 1
- Journal Page Range
- p. 45-48
- ISSN
- 0253-9950
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 35089583
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ADSORPTION; ALBUMINS; APATITES; BIOLOGICAL MODELS; BLOOD SERUM; COLLAGEN; DTPA; MICE; PHOSPHONATES; SAMARIUM 153; SAMARIUM COMPLEXES; SKELETON; UPTAKE
- Descriptors DEC
- AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY; BODY FLUIDS; CARBOXYLIC ACIDS; CHELATING AGENTS; COMPLEXES; DAYS LIVING RADIOISOTOPES; DRUGS; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOTOPES; MAMMALS; MATERIALS; MINERALS; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; ORGANS; PHOSPHATE MINERALS; PROTEINS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RARE EARTH COMPLEXES; RARE EARTH NUCLEI; RESPONSE MODIFYING FACTORS; RODENTS; SAMARIUM ISOTOPES; SCLEROPROTEINS; SORPTION; VERTEBRATES