Published July 1993 | Version v1
Journal article Metadata-only

A rapid synthesis of [fluoroacetyl-18F]fluoromelatonin (Nω-[18F]fluoroacetyl-5-methoxytryptamine), a potential diagnostic imaging agent

Creators

  • 1. Tohoku Univ., Sendai (Japan). Research Inst. for Tuberculosis and Cancer

Description

An efficient synthesis of [fluoroacetyl-18F]fluoromelatonin (Nω-[18F]Fluoroacetyl-5-methoxytryptamine) starting from [18F]fluoride and ethyl p-toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%, >98%, and 540 mCi/μmol, respectively. (Author)

Additional details

Publishing Information

Journal Title
Journal of Labelled Compounds and Radiopharmaceuticals
Journal Volume
33
Journal Issue
7
Journal Page Range
p. 601-606.
ISSN
0362-4803
CODEN
JLCRD4

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
25001911
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
CHEMICAL PREPARATION; FLUORINE 18; LABELLING; MELATONIN; ORGANIC FLUORINE COMPOUNDS; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS
Descriptors DEC
AMINES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; COMPUTERIZED TOMOGRAPHY; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NANOSEC LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS; TOMOGRAPHY; TRYPTAMINES