Published May 2001
| Version v1
Journal article
Comparison of in vivo dopamine D2 receptor binding of [123I]AIBZM and [123I]IBZM in rat brain
Description
[123I]AIBZM, (S)-5-[123I]-Iodo-N-[(1-ethyl-2-pyrrolidinyl)] methyl-4-amine-2-methoxybenzamide is a derivative with high affinity for the D2 receptor. Labeling was achieved by the IodogenTM method. The in vivo affinity for the D2 receptor and the biological characteristics were performed in rats. The brain uptake of [123I]AIBZM was significantly lower, however the striatum/cerebellum ratio (2h p.i.) was higher than that of [123I]IBZM. Because of the high affinity and its possibly lower unspecific binding compared to [123I]IBZM, [123I]AIBZM may be a potential imaging agent for the D2 dopamine receptor
Additional details
Identifiers
- PII
- S0969805101001998;
Publishing Information
- Journal Title
- Nuclear Medicine and Biology
- Journal Volume
- 28
- Journal Issue
- 4
- Journal Page Range
- p. 383-389
- ISSN
- 0969-8051
- CODEN
- NMBIEO
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 33025415
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BRAIN; CHEMICAL BONDS; DOPAMINE; IN VIVO; IODINE 123; LABELLED COMPOUNDS; RADIOPHARMACEUTICALS; RECEPTORS; UPTAKE
- Descriptors DEC
- AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BODY; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MEMBRANE PROTEINS; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYMPATHOMIMETICS
Optional Information
- Copyright
- Copyright (c) 2001 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.