A review on evaluation of technetium-99m labeled radiopharmaceuticals

In the past few years, substantial progress has been made in technetium chemistry, including the synthesis of a variety of ^99mTc-radiopharmaceuticals. This synthesis can be made feasible by using suitable reducing agents, highly specific ligands, appropriate buffer, and specific pH etc., which results in high radiochemical purity, minimum labeling time, commercial expediency of ⁹⁹Mo/^99mTc generator and high biological efficacy. ^99mTc-radiopharmaceuticals have confirmed their worth in every span of life, especially in clinical and medical applications. Now ^99mTc based pharmaceuticals are being used as diagnostic agents for a large number of infections caused by bacteria or any pathogens, tumors, cancers, ulcers etc. In this review, we discuss synthesis of a variety of ^99mTc carrying biological molecules (antibiotics/antibodies/peptides/amino acids/macro and micro-organic molecules) along with their applications, to overview key innovations. (author)