Biochemical and histopathological changes in mice suffering schistosomiasis in relation to exposure to irradiation and duration of infection

Quantitative estimations of serum components of mice were made before and at various intervals after infection of mice with normal and irradiated schistosoma mansoni cercaria. Moreover histopathological study was performed on the liver of infested mice at the end of experimentation. It showed that exposure of mice to irradiated cercariae produced mild degree of hepatic lesions. Significant increase in total protein values were observed after 35 days from infestation with normal cercariae with a moderate increase in the irradiated material. Indeed, small decrease in the albumin but an increase in globulin levels occurred as the result of reduced albumin globulin ratios particularly in the group of mice infested with irradiated cercariae