The pharmacokinetics of the drugs used in interventional therapy for Primary liver cancer: its current situation in research

For recent years, embolization agents has become one of the hot points in the discussion concerning transcatheter hepatic arterial chemoembolization (TACE) for liver carcinomas. A variety of embolic agents have been developed in order to improve the therapeutic effect of TACE. The embolic agents now used in TACE include irregular particles, spherical microspheres, drug-eluting microspheres, etc. The development of embolic agents is aimed at increasing the chemotherapy drug concentration within area and reducing peripheral blood drug concentration. Therefore, the anti-tumor efficacy can be improved, while its toxicity can be reduced. This paper aims to make a comprehensive review about the pharmacokinetic features of the drugs used in various interventional therapies for liver carcinomas. (authors)