Interim report on intrathoracic radiotherapy of human small-cell lung carcinoma in nude mice with Re-188-RC-160, a radiolabeled somatostatin analogue
Creators
- 1. RhoMed Inc., Albuquerque, NM (United States)
- 2. Univ. of Bonn (Germany). Dept. of Nuclear Medicine
- 3. Oak Ridge National Lab., TN (United States). Health Sciences Research Div.
Description
The purpose of this study was to evaluate the therapeutic efficacy of Re-188-RC-160 in experimental models of human small cell lung carcinomas which mimic the clinical presentation. In the experimental model, cells from the human small cell lung carcinoma cell line NCI-H69 cells were inoculated into the thoracic cavity of athymic mice and rats. Subsequently, the biodistribution of Re-188-RC-160 after injection into the pleural cavity, a radiolabeled somatostatin analogue, was monitored as was the effect on the subsequent growth of tumors. The results presented here, and which are a part of a larger series of studies, suggest that Re-188-RC-160 can be effectively used in this animal model to restrict the growth of small cell lung carcinoma in the thoracic cavity
Availability note (English)
MF available from INIS under the Report Number; Also available from OSTI as DE95014289; NTIS; US Govt. Printing Office Dep.Files
26076925.pdf
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Additional details
Publishing Information
- Imprint Pagination
- 17 p.
- Report number
- CONF-9505232--2
Conference
- Title
- 5. Mediterranean symposium on nuclear medicine and radiopharmaceuticals - receptors.
- Dates
- 23-28 May 1995.
- Place
- Athens (Greece).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 26076925
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Conference, Numerical Data
- Descriptors DEI
- CARCINOMAS; EVALUATION; EXPERIMENTAL DATA; EXPERIMENTAL NEOPLASMS; LUNGS; RADIOPHARMACEUTICALS; RADIOTHERAPY; RHENIUM 188; THERAPEUTIC USES
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DATA; DISEASES; DRUGS; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; INFORMATION; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MEDICINE; MINUTES LIVING RADIOISOTOPES; NEOPLASMS; NUCLEI; NUMERICAL DATA; ODD-ODD NUCLEI; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RESPIRATORY SYSTEM; RHENIUM ISOTOPES; THERAPY; USES
Optional Information
- Contract/Grant/Project number
- Contract AC05-84OR21400
- Funding organization
- USDOE, Washington, DC (United States).