Evaluation of the renal kinetic function, using MRI by gadolinium-DTPA
- 1. National Inst. of Radiological Sciences, Chiba (Japan)
Description
The evaluation of the renal kinetic function in rabbits, using MRI by Gd-DTPA was tried experimentally. The changes of Gd-DTPA concentration on relaxation rates (1/T1) followed continuously for 90 minutes after intravenous injection of Gd-DTPA (0.05 mmol/kg) with calculated T1 (300, 1000) images. GFR (glomeruler filtration ratio) values were calculated without blood sampling, and also regional MRI renography were made in the whole kidney, the renal cortex, the renal medulla and also the renal pelvis in the possible cases. Two kinds of renal dysfunction models were made, they were ureteral occlusion model in 5 rabbits and renal artery stenosed model in three rabbits. The calculated GRF value of the control rabbit was 3.7±0.9 ml/min. And the MRI regional renography and GFR values were useful for the detection of the regional renal function in the NMR tomographic image. In conclusion, the MRI renography using Gd-DTPA proposed useful data for regional renal kinetic study, and it will be possible to get GFR value without blood sampling. (author)
Additional details
Publishing Information
- Imprint Title
- Final report on the project research 'medical use of accelerated heavy ions'
- Imprint Pagination
- 239 p.
- Journal Page Range
- p. 215-221.
- Report number
- NIRS-R--19
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 22046776
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- DYNAMIC FUNCTION STUDIES; GADOLINIUM COMPOUNDS; IMAGES; KIDNEYS; NMR IMAGING; RABBITS; RADIOPHARMACEUTICALS; RENOGRAPHY; TIME DEPENDENCE
- Descriptors DEC
- ANIMALS; BODY; DIAGNOSTIC TECHNIQUES; DRUGS; LABELLED COMPOUNDS; MAMMALS; MATERIALS; ORGANS; RADIOACTIVE MATERIALS; RARE EARTH COMPOUNDS; VERTEBRATES