Published March 1986
| Version v1
Journal article
High yield synthesis of 6-[18F]fluoro-L-dopa
Creators
- 1. McMaster Univ. Medical Centre, Hamilton, Ontario
Description
The radiofluorination of L-dopa with [18F]F2 was investigated with the purpose of improving the yield of 6-[18F]fluoro-L-dopa. When boron trifluoride was added to the reaction mixture in hydrogen fluoride (HF), the yield was increased threefold. Nine millicuries of 6-[18F]fluoro-L-dopa were produced from 100 mCi [18F]F2 routinely and reliably after 2 hr of preparation. If acetonitrile or water were substituted for HF, little or no 6-fluoro-L-dopa was made
Additional details
Publishing Information
- Journal Title
- J. Nucl. Med.
- Journal Issue
- no.3
- Series
- J. Nucl. Med.
- ISSN
- 0022-3123
- CODEN
- JNMEA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 18013856
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ARSENIC; BORANES; CHEMICAL PREPARATION; CHEMICAL REACTION YIELD; DOPA; FLUORINATION; FLUORINE 18; LABELLED COMPOUNDS; LABELLING; SILANES
- Descriptors DEC
- AMINO ACIDS; AUTONOMIC NERVOUS SYSTEM AGENT; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BORON COMPOUNDS; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; DRUGS; ELEMENTS; FLUORINE ISOTOPES; HALOGENATION; HOURS LIVING RADIOISOTOPES; HYDRIDES; HYDROGEN COMPOUNDS; HYDROXY ACIDS; ISOTOPES; LIGHT NUCLEI; NEUROREGULATORS; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOISOTOPES; SEMIMETALS; SILICON COMPOUNDS; SYNTHESIS