Published November 2021 | Version v1
Journal article Metadata-only

68Ga-labelled-exendin-4: New GLP1R targeting agents for imaging pancreatic β-cell and insulinoma

Creators

  • 1. College of Chemistry, Beijing Normal University, Beijing (China)
  • 2. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing (China)

Description

Glucagon-like peptide-1 receptor (GLP1R) specifically expressed on the surface of pancreatic β-cells and insulinoma, is a potential biomarker for imaging β-cell mass (BCM). In this study, two new 68Ga-labelled GLP1R targeting agents were prepared and their biological properties for imaging BCM and insulinoma were evaluated.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.nucmedbio.2021.10.001

Additional details

Identifiers

DOI
10.1016/j.nucmedbio.2021.10.001;
PII
S0969805121005072;

Publishing Information

Journal Title
Nuclear Medicine and Biology
Journal Volume
102
Journal Page Range
p. 87-96
ISSN
0969-8051
CODEN
NMBIEO

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
53120582
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BIOLOGICAL MARKERS; GALLIUM 68; GLUCAGON; PANCREAS; RECEPTORS
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; DIGESTIVE SYSTEM; ELECTRON CAPTURE RADIOISOTOPES; ENDOCRINE GLANDS; GALLIUM ISOTOPES; GLANDS; HORMONES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; MEMBRANE PROTEINS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PEPTIDES; POLYPEPTIDES; PROTEINS; RADIOISOTOPES

Optional Information

Copyright
Copyright (c) 2021 Elsevier Inc. All rights reserved.