Published December 1986 | Version v1
Journal article Metadata-only

Potentiation of collagen synthesis in explants of the rabbit eye by 5 beta-dihydrocortisol

Creators

  • 1. New York Medical College, Valhalla

Description

The biologic effect of 5 beta-dihydrocortisol on collagen synthesis was evaluated. The metabolite was found to potentiate subthreshold levels of dexamethasone in increasing 3H-proline incorporation in cells of the outflow region of the rabbit. Digestion of the tissue with highly purified collagenase indicated that the 3H-proline was incorporated into collagen type protein. This study demonstrates another biologic activity of 5 beta-dihydrocortisol, a metabolite found to accumulate in cells cultured from trabeculectomy specimens from patients with primary open angle glaucoma

Additional details

Publishing Information

Journal Title
Invest. Ophthalmol. Visual Sci.
Journal Issue
no.12
Series
Invest. Ophthalmol. Visual Sci.
ISSN
0146-0404
CODEN
IOVSD

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
18056390
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
AUTORADIOGRAPHY; BIOLOGICAL EFFECTS; BIOSYNTHESIS; COLLAGEN; EYES; HYDROCORTISONE; IN VITRO; PROLINE; RABBITS; TRANSPLANTS; TRITIUM COMPOUNDS
Descriptors DEC
ADRENAL HORMONES; AMINES; AMINO ACIDS; ANIMALS; AZOLES; BODY; CARBOXYLIC ACIDS; CORTICOSTEROIDS; GLUCOCORTICOIDS; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; HORMONES; HYDROGEN COMPOUNDS; HYDROXY COMPOUNDS; KETONES; MAMMALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PREGNANES; PROTEINS; PYRROLES; PYRROLIDINES; SCLEROPROTEINS; SENSE ORGANS; STEROID HORMONES; STEROIDS; SYNTHESIS; VERTEBRATES