Published May 2013
| Version v1
Journal article
Chiral Pool Synthesis of N-Cbz-cis-(3R,4R)-3-methylamino-4-methylpiperidine from L-Malic acid
- 1. Zhejiang Univ., Hangzhou (China)
- 2. Luoyang Normal Univ., Luoyang (China)
- 3. Hutchison Medipharma Limited, Shanghai (China)
Description
A new synthetic route to N-Cbz-cis-(3R,4R)-3-methylamino-4-methylpiperidine, key intermediate for CP-690,550, was disclosed with L-malic acid as the chiral pool starting material. The title compound was obtained in 16 steps with a total yield of 26% and more than 98% ee
Additional details
Publishing Information
- Journal Title
- Bulletin of the Korean Chemical Society
- Journal Volume
- 34
- Journal Issue
- 5
- Series
- 54 refs, 7 figs
- Journal Page Range
- p. 1371-1377
- ISSN
- 0253-2964
INIS
- Country of Publication
- Korea, Republic of
- Country of Input or Organization
- Korea, Republic of
- INIS RN
- 45103517
- Subject category
- S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
- Descriptors DEI
- ENANTIOMORPHS; MALIC ACID; METHYLAMINE; SYNTHESIS
- Descriptors DEC
- AMINES; CARBOXYLIC ACIDS; HYDROXY ACIDS; ISOMERS; ORGANIC ACIDS; ORGANIC COMPOUNDS