Published 1990 | Version v1
Book Metadata-only

Radioimmunotherapy using 90Y-labelled monoclonal antifibrin antibody

Creators

  • 1. Helsinki Univ. Central Hospital (Finland). Meilahti Clinic
  • 2. Technical Research Centre of Finland, Espoo (Finland). Reactor Lab.
  • 3. Valtion Teknillinen Tutkimuskeskus, Espoo (Finland)
  • 4. Farmos-Group Ltd., Turku (Finland). Cancer Research Lab.

Description

Nude mice bearing human ovarian carcinoma xenografts were treated with 90Y-labeled monoclonal antifibrin antibody Fab fragment. The radioantibody was given intratumorally 4-7 times every 2-3 days. The survival time versus saline treated control group was significantly longer (p < .001) and also tumor growth was decreased. Another group of animals was treated with 90Y-labeled OC 125 monoclonal antibody; these mice received the therapy dose either intratumorally or intraperitoneally or intravenously. The survival time was longer in the intratumorally treated group (p < .001). The tissue distribution studies revealed that bone marrow is the critical organ and also that intratumorally injected monoclonal 90Y-antifibrin retains at least 36 hours after one therapy treatment in the xenograft causing cell death. 11 refs., 5 figs

Additional details

Publishing Information

Publisher
Wollongong University Printery Services.
Imprint Place
Wollongong (Australia)
ISBN
0 642 59902 5
Imprint Title
Advances in radiopharmacology: proceedings of the six international symposium on radiopharmacology
Imprint Pagination
314 p.
Journal Page Range
p. 232-237.

Conference

Title
6. International symposium on radiopharmacology.
Dates
24-26 Aug 1989.
Place
Sydney (Australia).

INIS

Country of Publication
Australia
Country of Input or Organization
Australia
INIS RN
22019233
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
CARCINOMAS; EXPERIMENTAL NEOPLASMS; FIBRIN; GROWTH; HISTOLOGICAL TECHNIQUES; IMMUNOTHERAPY; LABELLED COMPOUNDS; MICE; MONOCLONAL ANTIBODIES; OVARIES; RADIONUCLIDE ADMINISTRATION; RADIOTHERAPY; SURVIVAL TIME; TISSUE DISTRIBUTION; TUMOR CELLS; YTTRIUM 90
Descriptors DEC
ANIMAL CELLS; ANIMALS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BLOOD COAGULATION FACTORS; BODY; COAGULANTS; DAYS LIVING RADIOISOTOPES; DISEASES; DISTRIBUTION; DRUGS; FEMALE GENITALS; GONADS; HEMATOLOGIC AGENTS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MEDICINE; NEOPLASMS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES; RODENTS; SCLEROPROTEINS; THERAPY; VERTEBRATES; YTTRIUM ISOTOPES