Published December 1997 | Version v1
Journal article Metadata-only

Radiosensitizer AK-2123 enhances cytotoxic and cytostatic activity of splenocytes and macrophages in lewis lung carcinoma bearing mice treated with cyclophosphamide

Creators

  • 1. Cancer Research Institute, Russian Academy of Medical Sciences, Tomsk (Russian Federation)
  • 2. Institute of Chemical Physics, Russian Academy of Sciences, Chernogolovka (Russian Federation)
  • 3. Japan Radiosensitization Research Association, Japan (Japan)

Description

The ability of hypoxic radiosensitizer AK-2123 to modulate the activity of immunocompetent cells in health mice and in Lewis lung carcinoma bearing mice treated with cyclophosphamide (CPA) was investigated. The simulating influence of AK-2123 on splenocytes natural killer activity and anti proliferative activity of lymphocytes and macrophages were revealed. Our data demonstrate that the increase in CPA therapeutic efficacy by AK-2123 is associated with augmented natural killer activity of splenocytes and with their higher anti proliferative effect

Additional details

Additional titles

Original title (Russian)
Усиление цитотоксической и цитостатической активности спленоцитов и макрофагов радиосенсибилизатором AK-2123 у мышей с карциномой льюис при терапии циклофосфаном

Publishing Information

Journal Title
Ehksperimental'naya Onkologiya
Journal Volume
19
Journal Issue
4
Journal Page Range
p. 333-337.
ISSN
0204-3564
CODEN
EKSODD

INIS

Country of Publication
Ukraine
Country of Input or Organization
Ukraine
INIS RN
29029583
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CARCINOMAS; DOSE-RESPONSE RELATIONSHIPS; ENDOXAN; MICE; RADIOSENSITIVITY; RADIOSENSITIZERS; RADIOTHERAPY; TRIAZOLES
Descriptors DEC
ALKYLATING AGENTS; ANIMALS; ANTIMITOTIC DRUGS; AZOLES; DISEASES; DRUGS; HETEROCYCLIC COMPOUNDS; IMMUNOSUPPRESSIVE DRUGS; MAMMALS; MEDICINE; NEOPLASMS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RESPONSE MODIFYING FACTORS; RODENTS; THERAPY; VERTEBRATES