Published December 4, 1986 | Version v1
Journal article Metadata-only

Radioiodine-labelled metaiodobenzylguanidine (MIBG) for scintigraphic detection and treatment of pheochromocytomas and neuroblastomas

Creators

  • 1. Hopital St-Andre, 33 Bordeaux (France)
  • 2. Hopital Pellegrin, 33 Bordeaux (France)
  • 3. Hopital Haut-Leveque, 33 Bordeaux-Pessac (France)

Description

The new synthetic molecule radioiodine-labelled metaiodobenzylguanidine (MIBG) is a structural analogue to catecholamines that is trapped by adrenergic storage vesicles. Because of its affinity for chromaffin tissues. MIBG is suitable for the scintigraphic detection and localization of pheochromocytomas. Radioiodine-labelled MIBG isotopic scan is especially useful, as compared to computed tomography, for the detection of extra-adrenal tumor sites, multiple tumors and metastases from malignant pheochromocytomas. MIBG also shows affinity for neuroblastomas and their metastases. I131-MIBG in therapeutic doses is a promising tool for the treatment of malignant pheochromocytomas and their metastases

Abstract (French)

La meta-iodobenzylguanidine marquee a l'iode radioactif est une nouvelle molecule de synthese qui est un analogue structural des catecholamines, captee par les vesicules de stockage adrenergiques. Son affinite pour les tissus chromaffines permet son utilisation pour le diagnostic et la localisation scintigraphique des pheochromocytomes. En comparaison de la tomodensitometrie, la scintigraphie par la meta-iodobenzylguanidine radio-iodee est particulierement utile pour la mise en evidence des localisations extrasurrenaliennes, des formes multiples et des metastases des formes malignes de pheochromocytomes. La meta-iodobenzylguanidine se fixe egalement dans les neuroblastomes et leurs metastases. L'utilisation de la I131 meta-iodobenzylguanidine a doses therapeutiques ouvre de nouvelles perspectives pour le traitement des pheochromocytomes malins et leurs metastases

Additional details

Additional titles

Original title (French)
La meta-iodobenzylguanidine marquee a l'iode radioactif dans la detection scintigraphique et le traitement des pheochromocytomes et des neuroblastomes

Publishing Information

Journal Title
Sem. Hop. Paris
Journal Volume
62
Journal Issue
44
Series
Sem. Hop. Paris.
Journal Page Range
3567-3572
ISSN
0037-1777
CODEN
SHPAA

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
18041660
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ADRENAL GLANDS; DIAGNOSIS; GUANIDINES; IODINE 131; METASTASES; NEOPLASMS; PATIENTS; RADIOPHARMACEUTICALS; RADIOTHERAPY; SCINTISCANNING
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBONIC ACID DERIVATIVES; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ENDOCRINE GLANDS; GLANDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; THERAPY