Role of Some Micro nutrients in Ameliorating the Destructive Effect of Trichloroethylene on Kidney and Testes of Male Rats

Trichloroethylene (TCE) is a widely used volatile compound to which considerable numbers of human are exposed via breathing , through the skin or through drinking water but rarely through food. The main symptoms of exposure are headache, dizziness, and confusion. Beyond the effects to the central nervous system, workplace exposure to TCE has been associated with toxic effects in many organs including kidney and testes.This work aim to investigate the role of vitamin C and / or zinc against the destructive effect of daily oral TCE intake through biochemical, tissue and DNA studies for kidney and testes during short (3 weeks) and long (15 weeks) terms. Also a hematological study for complete blood count (CBC) has been carried out.The results showed that TCE increases the level of urea creatinine and uric acid and decreases the level of total testosterone significantly. It also showed deformation in tissues and DNA degradation after short and long term treatment with TCE. Administration of vitamin C and/or zinc improved the disrupted effect of TCE oral intake in all the investigated parameters either significantly or non-significantly.It could be conclude d that, both occupational workers and normal people whom may be exposed to TCE can use vitamin C and/ or zinc to compensate the TCE hazardous effect