Published November 2018 | Version v1
Journal article Metadata-only

Comparison of the Structural Features of Micron and Submicron Vaterite Particles and Their Efficiency for Intranasal Delivery of Anesthetic to the Brain

Creators

  • 1. National Research Centre "Kurchatov Institute," (Russian Federation)
  • 2. Shubnikov Institute of Crystallography, Federal Scientific Research Centre "Crystallography and Photonics," Russian Academy of Sciences (Russian Federation)
  • 3. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences (Russian Federation)

Description

Nanostructured spherical calcium carbonate particles with average sizes of 3.8 µm and 550 nm have been fabricated. Optimal conditions for adsorption of central anesthetic loperamide on these particles are found. The influence of particle size on the adsorption efficiency is studied. The efficiency of micron and submicron vaterite particles as carriers for intranasal loperamide delivery is compared using in vivo tests on laboratory animals.

Additional details

Identifiers

DOI
10.1134/S1063774518060305;

Publishing Information

Journal Title
Crystallography Reports
Journal Volume
63
Journal Issue
6
Journal Page Range
p. 998-1004
ISSN
1063-7745
CODEN
CYSTE3

INIS

Country of Publication
Russian Federation
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
51091353
Subject category
S77: NANOSCIENCE AND NANOTECHNOLOGY;
Descriptors DEI
ADSORPTION; ANESTHETICS; BRAIN; CALCIUM CARBONATES; CARRIERS; COMPARATIVE EVALUATIONS; IN VIVO; LABORATORY ANIMALS; NANOSTRUCTURES; PARTICLE SIZE; SPHERICAL CONFIGURATION
Descriptors DEC
ALKALINE EARTH METAL COMPOUNDS; ANIMALS; BODY; CALCIUM COMPOUNDS; CARBON COMPOUNDS; CARBONATES; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CONFIGURATION; DRUGS; EVALUATION; NERVOUS SYSTEM; ORGANS; OXYGEN COMPOUNDS; SIZE; SORPTION

Optional Information

Copyright
Copyright (c) 2018 Pleiades Publishing, Inc.