Published May 1992
| Version v1
Journal article
The synthesis of [14C]pantoprazole - SK and F 96022Z
- 1. SmithKline Beecham Research, Welwyn (United Kingdom)
Description
Pantoprazole 1, SK and F 96022Z, an H+/K+ ATPase inhibitor has been prepared, radiolabelled with carbon-14, in two positions, for drug metabolism studies. [Benzimidazole-2-14C]Pantoprazole in 4 steps from potassium ethyl [14C]xanthate, and [pyridylmethyl-14C]pantophazole from cuprous [14C]cyanide in 8 steps. The overall radiochemical yields of these syntheses were 37.9% and 5.2% respectively. (author)
Additional details
Publishing Information
- Journal Title
- Journal of Labelled Compounds and Radiopharmaceuticals
- Journal Volume
- 31
- Journal Issue
- 5
- Series
- J. Labelled Compd. Radiopharm.
- Journal Page Range
- 409-416
- ISSN
- 0362-4803
- CODEN
- JLCRD
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 23085577
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ATP-ASE; AZOLES; CARBON 14; DRUGS; ENZYME INHIBITORS; GASTROINTESTINAL TRACT; LABELLED COMPOUNDS; METABOLISM; RADIOPHARMACEUTICALS; SYNTHESIS
- Descriptors DEC
- ACID ANHYDRASES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBON ISOTOPES; DIGESTIVE SYSTEM; ENZYMES; EVEN-EVEN NUCLEI; HETEROCYCLIC COMPOUNDS; HYDROLASES; ISOTOPES; LIGHT NUCLEI; MATERIALS; NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PHOSPHOHYDROLASES; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPES; YEARS LIVING RADIOISOTOPES