Feasibilities of application of proteinases labelled with iodine radioactive isotopes, of their predecessors inhibitors and substrates in assessment of tumor effect on the organisms

A comparative study of the behaviour of proteinases labelled with iodine of proteinase predecessors, of inhibitors in intact animals and in animals with transplanted tumors was carried out. Data on the increase of the intensity of radioactive substance excretion with urine following injection of ephatine-125I to animals with tumors (by 2 fold in relation to intact animals during 1 h) and on decrease of the radioactive substance buildup in gastro-intestinal tract are obtained. These processes are connected with the change of the given high molecular compound concentration induced by tumor growht