The effect of KS and CP on hematopoiesis regulation in irradiated mice

Objective: Investigate the effect of KS and CP on hematopoietic reconstitution in irradiated mice. Methods; C57 BL/6 mice were divided into four groups randomly, such as blank control group, irradiation control group, irradiation with KS group and irradiation with CP group. The last three groups were underwent irradiation of 5.5 Gy ¹³⁷Cs - γ rays, and the dose rate was 1 Gy/min. After irradiation treatment, mice in KS groups were given KS orally (1.5 g/kg) twice every three days, mice in CP groups were given CP orally (2.7 g/kg) twice every three days, and mice in two control groups were given normal saline orally twice every three days. Peripheral blood was checked every month after irradiation. Another group of mice were divided into 4 groups identically, given KS, CP or normal saline everyday after treated with 5.5 Gy ¹³⁷Cs - γ rays. CFU-F was tested one month after radiation. Results: The number of white blood cell and lymphocyte in KS group and CP group was higher than irradiation control group. Conclusion: KS and CP can promote hematopoietic recovery in irradiated mice. (authors)