Published 1979 | Version v1
Book Metadata-only

Transport of /sup 99m/Tc complexes through the blood-brain barrier

Creators

  • 1. Univ. of Maryland, Baltimore

Description

Thirteen /sup 99m/Tc complexes have been synthesized and used to determine the relationships between protein binding, lipophilicity and membrane transport. The lipophilicity of the /sup 99m/Tc complexes was altered by adding substituents to either IDA, EDTA, DTPA or oxine; membrane transport was estimated using the brain uptake index (BUI) method. The BUI of the /sup 99m/Tc complexes was found to vary directly with lipophilicity and inversely with protein binding. These results demonstrated that /sup 99m/Tc-oxine derivatives are better suited for use in the development of intracellular tracers than are the /sup 99m/Tc derivatives of aminopolycarboxylates

Additional details

Publishing Information

Publisher
Society of Nuclear Medicine, Inc.
Imprint Place
New York, NY
Imprint Title
Radiopharmaceuticals. II
Journal Page Range
p. 449-458.

Conference

Title
2. international symposium on radiopharmaceuticals.
Dates
18 - 23 Mar 1979.
Place
Seattle, WA, USA.

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
12592054
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BLOOD-BRAIN BARRIER; BRAIN; COMPARATIVE EVALUATIONS; CPB; DIFFUSION; ISOMERIC NUCLEI; MEMBRANES; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; TECHNETIUM COMPLEXES; TECHNETIUM 99
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; COMPLEXES; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPLEXES; YEARS LIVING RADIOISOTOPES