Published November 1992 | Version v1
Journal article Metadata-only

Synthesis of 3-[18F]-fluoromethyl-TCP1, a potential tool for PET study of the NMDA receptor channel complex

Creators

  • 1. CEA, 91 - Orsay (France). Service Hospitalier Frederic Joliot
  • 2. CNRS UPR 8402-INSERM, Montpellier (France)

Description

In an attempt to visualize the NMDA glutamatergic receptors and after checking the biological activity of the cold 3-fluoromethyl-TCP, 3-[18F]-fluoro-methyl-TCP was synthesized by a nucleophilic substitution of 3-bromomethyl-TCP with [18F-]. (author)

Additional details

Publishing Information

Journal Title
Journal of Labelled Compounds and Radiopharmaceuticals
Journal Volume
31
Journal Issue
11
Journal Page Range
p. 955-960.
ISSN
0362-4803
CODEN
JLCRD4

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
24035224
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
BRAIN; CHEMICAL PREPARATION; FLUORINE 18; LABELLING; ORGANIC FLUORINE COMPOUNDS; PIPERIDINES; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS
Descriptors DEC
AMINES; AZINES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NANOSEC LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIDINES; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS; TOMOGRAPHY